Mon, May 23, 2022

Laboratory and Transplant

 | Post date: 2019/03/3 | 
Laboratory and Transplant

1-Naderi H, Pourmand G, Dehghani S, Nikoueinejad H, Jafari M, Tajik N. Monitoring cellular immune function of renal transplant recipients based on adenosine triphosphate (ATP) production by mitogen-induced CD4+ T helper cells. Biomed Pharmacother. 2018 Nov;107:1402-1409. Doi: 10.1016/j.biopha.2018.08.110.
2-Jafari R, Aflatoonian R, Falak R, Pourmand G, Dehghani S, Mortazavi M, Adelipour A, Rezaei A, Tajik N. Down-regulation of inflammatory signaling pathways despite up-regulation of Toll-like receptors; the effects of corticosteroid therapy in brain-dead kidney donors, a double-blind, randomized, controlled trial. Mol Immunol. 2018 Feb;94:36-44. Doi: 10.1016/j.molimm.
3-Mohammadi Ayenehdeh J, Niknam B, Rasouli S, Hashemi SM, Rahavi H, Rezaei N, Soleimani M, Liaeiha A, Niknam MH, Tajik N. Immunomodulatory and protective effects of adipose tissue-derived mesenchymal stem cells in an allograft islet composite transplantation for experimental autoimmune type 1 diabetes. Immunol Lett. 2017 Aug;188:21-31. Doi: 10.1016/j.imlet.2017.05.006. Epub 2017 May 12.
4-Gholamnezhadjafari R, Tajik N, Falak R, Aflatoonian R, Dehghan S, Rezaei A. Innate inflammatory gene expression profiling in potential brain-dead donors: detailed investigation of the effect of common corticosteroid therapy. Innate Immun.2017Jul;23(5):440-448.Doi: 10.1177/1753425917709508. Epub 2017 May 15.
5-Mohammadi Ayenehdeh J, Niknam B, Hashemi SM, Rahavi H, Rezaei N, Soleimani M, Tajik N. Introducing a New Experimental Islet Transplantation Model using Biomimetic Hydrogel and a Simple High Yield Islet Isolation Technique. Iran Biomed J. 2017 Jul;21(4):218-27. Epub 2017 Jun 6.

Nowadays, application of transplantation for replacement of damaged tissues and organs is given a valuable position in modern medical treatments. Notably, pre- and post-transplant medical laboratory services had a great impact for achieving this situation. In the “medical laboratory and transplantation” panel, several topics including history of transplant lab in Iran, tissue typing techniques and required histocompatibility between donor and recipient in various types of transplants, methodology of analysis and clinical impact of anti-HLA antibodies, using biomarkers in early detection of allograft rejection, and some special tests for hematopoietic stem cells transplantation (HSCT) are discussed. We hope that improvement in Iranian transplant registries and standardization of transplant laboratory protocols will eventually lead us to a bright and suitable position in the region and in the world. Furthermore, considerable increases in organs of brain-dead donors compared to living-unrelated donors in the last decade at our transplant centers has directed us to a serious attention to histocompatibility testing. Due to inflammatory condition, organs from brain-dead donors are more immunogenic than living ones to induce graft rejection and more tissue matching is critical.


Dr. Nader Tajik

- DCLS and PhD in immunology from Tehran University of Medical Sciences
- Professor at Department of Immunology, School of Medicine, Iran University of Medical Sciences
- Main focus of research on immunohistochemistry and transplantation
- Advisor and supervisor of several dissertations in postgraduate studies with corresponding extracted articles published in
accredited international journals

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